MOLECULAR ONCOLOGY

  • Molecular Oncology

MOLECULAR INFECTIVITY

  • Molecular infectivology

We will be ready to launch the service within the end of 2017

Molecular Oncology diagnostic services to analyse genes

BRCA1 BRCA2 TP53 APC MSH2 MLH1

Genechron cancer molecular diagnostic services cancer analysis molecular tumor genes MutS genes cancer Protein Homolog 2 MutL Homolog 1cancer DNA development optimal ovarian mutational oncology cancer analysis oncology amplification cancer Lynch syndrome sequencing conditions tumor oncology analysis mutational DNA analysis Lynch syndrome oncology genes analysis molecular oncology following tumor genes BRCA1 BRCA2 TP53 APC MSH2 MLH1 DNA TP53 gene mutations Specific mutations cancer gene codes ovarian cancer BRCA2 TP53 APC MSH2 MLH1 DNA TP53 DNA repair Tumor Protein Adenomatous Polyposis Coli cancer Genechron cancer molecular diagnostic services cancer analysis molecular tumor genes MutS genes cancer Protein Homolog 2 and MutL Homolog 1cancer DNA development optimal ovarian mutational oncology cancer analysis oncology amplification cancer Lynch syndrome sequencing conditions tumor oncology analysis mutational DNA analysis Lynch syndrome for oncology genes analysis molecular oncology following tumor genes BRCA1 BRCA2 TP53 APC MSH2 MLH1 DNA TP53 gene mutations Specific mutations cancer gene codes ovarian cancer BRCA2 TP53 APC MSH2 MLH1 DNA TP53 DNA repair Tumor Protein Adenomatous Polyposis Coli cancer

Genechron S.r.l. offers molecular diagnostic services to analyse genes involved in the susceptibility of cancer development. Genechron designs and synthesizes its own specific primers  to set-up optimal amplification and sequencing conditions.  The service includes complete coding regions sequencing and mutational analysis for the following genes: BRCA1, BRCA2, TP53, APC, MSH2 and MLH1.

BRCA1/2

The BRCA1/2 (Breast Cancer Type 1/2 Cancer Susceptibility) genes code for proteins acting as tumor suppressors, as being involved in repairing damaged DNA. They play a critical role in maintaining the stability of a cell's genetic information. Specific mutations of these genes are associated with an increased risk of breast cancer in both men and women, as well as several other types of cancer.

TP53

TP53 (Tumor Protein 53) gene codes for a protein called tumor protein p53 which acts as a tumor suppressor: it regulates cell division by avoiding cells from growing or dividing too fast or in an uncontrolled way. TP53 gene mutations have been found in some cases of bladder cancer, breast and ovarian cancer, head and neck squamous cell carcinomas and Li-Fraumeni syndrome.

APC

The APC (Adenomatous Polyposis Coli) gene codes for a protein which plays a critical role as a tumor suppressor:  it regulates cell division by avoiding cells from growing or dividing too fast or in an uncontrolled way. Several mutations in the APC gene have been found in desmoid tumor, familial adenomatous and Turcot syndrome.

MSH2/MLH1

The MSH2/MLH1 (MutS Protein Homolog 2 and MutL Homolog 1) genes code for proteins involved in DNA repair. These proteins help fix mistakes that are made when DNA is copied (DNA replication) in preparation for cell division. Several mutations in these genes are involved in Lynch syndrome and ovarian cancer.